LEADERSHIP

Our passion is to develop important, disease-modifying therapies for devastating pulmonary diseases – and Cystic Fibrosis is the first target on our list.

We are building a dedicated team of scientists, clinical staff, management and advisors with the skills and vision to make this a reality.

Tim Shannon, MD

Chair

Dr. Shannon is a board-certified pulmonologist with multidisciplined experience in research, strategic drug development, and medical and clinical affairs, including prior roles in industry, academia, and clinical practice. He is a General Partner in the healthcare practice at Canaan Partners focused on early-stage investing. In this role, he was the founding CEO of Canaan portfolio companies Arvinas and Aldea and sits on the boards of IDEAYA Biosciences, Nextcure, Arvinas (Chair), and Vivace Therapeutics.

Previous to joining Canaan, Dr. Shannon was President and CEO of CuraGen, a publicly traded biopharmaceutical company. Earlier, he was Senior Vice President of Global Medical and Clinical Development for Bayer Pharmaceuticals, responsible for all strategic and operational aspects of clinical development and drug safety. Prior to his career in industry, Dr. Shannon was an Assistant Professor in the Pulmonary and Critical Care Division at Yale University School of Medicine and an Attending Physician in Pulmonary and Critical Care Medicine at the West Haven VA Medical Center.

Dr. Shannon received his postgraduate medical training at the Beth Israel Hospital of Harvard Medical School and Boston University. He earned his medical degree from the University of Connecticut and has a BA in Chemistry from Amherst College.

Alistair Wheeler, MD MFPM

Chief Medical Officer

Alistair leads the Company’s clinical development, medical affairs and regulatory strategy functions. He is a pulmonologist with nearly 35 years of global drug development experience, including work across all phases of development with both small molecules and biologics. He has been personally responsible for over 30 INDs/CTAs and had key roles in the filing of nine successful marketing applications with regulatory agencies worldwide. A large majority of this work has been focused in the respiratory field, developing products for nasal allergy, rhinitis, asthma, COPD, and pneumonia. Additionally, Alistair’s family has a connection to Cystic Fibrosis that fuels his passion to make a meaningful impact on this disease.

Prior to joining Spyryx, Alistair was the Global Head of Clinical Development, Respiratory Medicine and Biotherapeutics at Sunovion Pharmaceuticals, where he was responsible for leading the clinical development of SUN-101 for COPD from Phase 2 to successful NDA filing. He also supported clinical expansion for Sunovion’s approved products in multiple therapeutic areas. Before Sunovion, Alistair was Senior Director, Clinical Research at Cubist Pharmaceuticals, heading the clinical research function for development programs in infectious disease and cardiovascular surgery, as well as leading the clinical support for marketed products. Alistair’s earlier clinical development and medical affairs experience included positions in both the US and Europe at Avant Immunotherapeutics, Astra USA, Hoffmann-LaRoche, and Glaxo.

Alistair earned his MD from the Royal London Hospital Medical College and his MFPM from the Royal College of Physicians. He is a member of the American Thoracic Society and former vice president of the American Academy of Pharmaceutical Physicians.

Timm Crowder, PhD

SVP, Technical Operations

Timm’s responsibilities include Spyryx’s technology and preclinical product development efforts, the manufacturing supply chain and quality system for Spyryx’s product candidates, and oversight of Spyryx’s intellectual property portfolio. He is an inhalation and manufacturing technology expert credited with 10 issued patents on inhalers and powder filling systems and more than 25 publications, book chapters and international presentations relating to aerosol drug delivery, inhaler design, powder filling, and product formulation and characterization.

He came to Spyryx from GlaxoSmithKline where he was most recently Director of Advanced Manufacturing Technology, leading innovation in the areas of aerosol and dry powder inhaler release testing, technology enhanced manufacturing strategies, electronic inhaler and particle engineering technologies. Earlier in his tenure at GSK, he contributed to the development of manufacturing systems and quality-by-design for GSK’s current asthma and COPD products. Prior to GSK, Timm was co-founder and Chief Technology Officer of Oriel Therapeutics, an inhaler technology company launched to commercialize device designs he developed during his graduate research. Oriel was subsequently acquired by Sandoz Pharmaceuticals.

Timm earned his PhD in Biomedical Engineering from UNC-Chapel Hill and has degrees in Physics from North Carolina State University and Davidson College.