Our passion is to develop important, disease-modifying therapies for devastating pulmonary diseases – and Cystic Fibrosis is the first target on our list.

We are building a dedicated team of scientists, clinical staff, management and advisors with the skills and vision to make this a reality.

Christy Shaffer, PhD

Vice Chair

Dr. Shaffer is a entrepreneur, biotech executive, and venture investor with over 25 years of experience in the life science industry. She joined Hatteras Venture Partners in 2011 as Managing Director of Hatteras Discovery and became a General Partner in 2016. In addition to serving as Vice Chair for Spyryx, Dr. Shaffer sits on five other Hatteras portfolio company boards and chairs four of them: Artizan Biosciences (Chair), Clearside Biomedical (Chair), GrayBug Vision (Chair), Trefoil Therapeutics (Chair), and G1 Therapeutics. She is a former member of the board of trustees of the Cystic Fibrosis Foundation (CFF) and past board chair of Cystic Fibrosis Foundation Therapeutics, Inc., the nonprofit drug development affiliate of CFF. She received the Breath of Life Award from CFF in 2009.

Following her career at Burroughs Wellcome, she joined Inspire Pharmaceuticals as the first full-time employee, ultimately becoming President and CEO. She was responsible for raising over $300 million for the company, including taking the company public in 2000, and growing annual revenues to over $100 million.

Dr. Shaffer earned her Ph.D. in Pharmacology from the University of Tennessee and did post-doctoral training at Chicago Medical School and UNC-Chapel Hill.

Alistair Wheeler, MD MFPM

Chief Medical Officer

Alistair leads the Company’s clinical development, medical affairs and regulatory strategy functions. He is a pulmonologist with nearly 35 years of global drug development experience, including work across all phases of development with both small molecules and biologics. He has been personally responsible for over 30 INDs/CTAs and had key roles in the filing of nine successful marketing applications with regulatory agencies worldwide. A large majority of this work has been focused in the respiratory field, developing products for nasal allergy, rhinitis, asthma, COPD, and pneumonia. Additionally, Alistair’s family has a connection to Cystic Fibrosis that fuels his passion to make a meaningful impact on this disease.

Prior to joining Spyryx, Alistair was the Global Head of Clinical Development, Respiratory Medicine and Biotherapeutics at Sunovion Pharmaceuticals, where he was responsible for leading the clinical development of SUN-101 for COPD from Phase 2 to successful NDA filing. He also supported clinical expansion for Sunovion’s approved products in multiple therapeutic areas. Before Sunovion, Alistair was Senior Director, Clinical Research at Cubist Pharmaceuticals, heading the clinical research function for development programs in infectious disease and cardiovascular surgery, as well as leading the clinical support for marketed products. Alistair’s earlier clinical development and medical affairs experience included positions in both the US and Europe at Avant Immunotherapeutics, Astra USA, Hoffmann-LaRoche, and Glaxo.

Alistair earned his MD from the Royal London Hospital Medical College and his MFPM from the Royal College of Physicians. He is a member of the American Thoracic Society and former vice president of the American Academy of Pharmaceutical Physicians.

Timm Crowder, PhD

SVP, Technical Operations

Timm’s responsibilities include Spyryx’s technology and preclinical product development efforts, the manufacturing supply chain and quality system for Spyryx’s product candidates, and oversight of Spyryx’s intellectual property portfolio. He is an inhalation and manufacturing technology expert credited with 10 issued patents on inhalers and powder filling systems and more than 25 publications, book chapters and international presentations relating to aerosol drug delivery, inhaler design, powder filling, and product formulation and characterization.

He came to Spyryx from GlaxoSmithKline where he was most recently Director of Advanced Manufacturing Technology, leading innovation in the areas of aerosol and dry powder inhaler release testing, technology enhanced manufacturing strategies, electronic inhaler and particle engineering technologies. Earlier in his tenure at GSK, he contributed to the development of manufacturing systems and quality-by-design for GSK’s current asthma and COPD products. Prior to GSK, Timm was co-founder and Chief Technology Officer of Oriel Therapeutics, an inhaler technology company launched to commercialize device designs he developed during his graduate research. Oriel was subsequently acquired by Sandoz Pharmaceuticals.

Timm earned his PhD in Biomedical Engineering from UNC-Chapel Hill and has degrees in Physics from North Carolina State University and Davidson College.