In particular, CF has a profound effect on the lungs and respiratory tract, characterized by dehydration of the airway surface and reduced mucus clearance – the lung’s principle mechanism for maintaining a clean environment. The mucus becomes thick and sticky, progressively accumulating into obstructions that block airflow and result in recurrent colonization of the airways by viruses and bacteria. This condition leads to frequent, acute lung infections, chronic inflammation, and impaired lung function. The long-term result of the disease is progressive, permanent tissue damage and scarring (fibrosis) in the lung. No cure for CF is known, although several treatments have been approved to address the underlying cause of the disease for some CFTR mutations.